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Spatial Extent of Charge Repulsion Regulates Assembly Pathways for Lysozyme Amyloid Fibrils

Formation of large protein fibrils with a characteristic cross β-sheet architecture is the key indicator for a wide variety of systemic and neurodegenerative amyloid diseases. Recent experiments have strongly implicated oligomeric intermediates, transiently formed during fibril assembly, as critical...

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Библиографические подробности
Главные авторы: Hill, Shannon E., Miti, Tatiana, Richmond, Tyson, Muschol, Martin
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071722/
https://ncbi.nlm.nih.gov/pubmed/21483680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018171
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