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Total Synthesis of Rhazinilam: Axial to Point Chirality Transfer in an Enantiospecific Pd-Catalyzed Transannular Cyclization

[Image: see text] A total synthesis of rhazinilam based on a transannular cyclization strategy is described. Using a Heck reaction, the axial chirality of a halogenated 13-membered lactam can be exploited to create the quaternary chiral stereogenic center in the target molecule with high enantiospec...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gu, Zhenhua, Zakarian, Armen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071635/
https://ncbi.nlm.nih.gov/pubmed/20795730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol101523z
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