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A novel suicide substrate for DNA topoisomerases and site-specific recombinases.

DNA topoisomerases and DNA site-specific recombinases are biologically important enzymes involved in a diverse set of cellular processes. We show that replacement of a phosphodiester linkage by a 5'-bridging phosphorothioate linkage creates an efficient suicide substrate for calf thymus topoisomeras...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Burgin, A B, Huizenga, B N, Nash, H A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1995
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307138/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7659520/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.15.2973
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