In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection

Hypoxia is a key determinant of tumor aggressiveness, yet little is known regarding hypoxic global gene regulation in vivo. We have employed the hypoxia marker EF5 coupled with laser capture microdissection to isolate RNA from viable hypoxic and normoxic regions of 9L experimental gliomas. Through m...

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Detalhes bibliográficos
Main Authors: Marotta, Diane, Karar, Jayashree, Jenkins, W. Timothy, Kumanova, Monika, Jenkins, Kevin W., Tobias, John W., Baldwin, Donald, Hatzigeorgiou, Artemis, Alexiou, Panagiotis, Evans, Sydney M., Alarcon, Rodolfo, Maity, Amit, Koch, Cameron, Koumenis, Constantinos
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071295/
https://ncbi.nlm.nih.gov/pubmed/21266355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3061
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