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Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA.

The structural motif formed between a hammerhead ribozyme and its substrate consists of three RNA double helices in which the sequence 5' to the XUY is termed helix I and the sequence 3' to the XUY helix III. Two hammerhead ribozymes targeted to the tat gene of HIV-1SF2 were designed to study target...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Principais autores: Sun, L Q, Wang, L, Gerlach, W L, Symonds, G
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1995
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307129/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7544887/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.15.2909
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