L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue

PURPOSE: Human hypothalamic hamartomas (HHs) are associated with gelastic seizures, intrinsically epileptogenic, and notoriously refractory to medical therapy. We previously reported that the L-type calcium channel antagonist nifedipine blocks spontaneous firing and γ-aminobutyric acid (GABA)(A)–ind...

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Главные авторы: Simeone, Kristina A, Sabesan, Shivkumar, Kim, Do Young, Kerrigan, John F, Rho, Jong M, Simeone, Timothy A
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2011
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Full-Length Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071288/
https://ncbi.nlm.nih.gov/pubmed/21269296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2010.02942.x
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