Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland

Elevated circulating estrogen levels are associated with increased risk of breast cancer in obese postmenopausal women. Following menopause, the biosynthesis of estrogens through CYP19 (aromatase)-mediated metabolism of androgen precursors occurs primarily in adipose tissue, and the resulting estrog...

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Main Authors: Subbaramaiah, Kotha, Howe, Louise R., Bhardwaj, Priya, Du, Baoheng, Gravaghi, Claudia, Yantiss, Rhonda K., Zhou, Xi Kathy, Blaho, Victoria A., Hla, Timothy, Yang, Peiying, Kopelovich, Levy, Hudis, Clifford A., Dannenberg, Andrew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071249/
https://ncbi.nlm.nih.gov/pubmed/21372033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0381
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