Bacterial Pore-Forming Cytolysins Induce Neuronal Damage in a Rat Model of Neonatal Meningitis

Background. Group B Streptococcus (GBS) and Streptococcus pneumoniae (SP) are leading causes of bacterial meningitis in neonates and children. Each pathogen produces a pore-forming cytolytic toxin, β-hemolysin/cytolysin (β-h/c) by GBS and pneumolysin by SP. The aim of this study was to understand th...

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Main Authors: Reiß, Anja, Braun, Johann S., Jäger, Katja, Freyer, Dorette, Laube, Gregor, Bührer, Christoph, Felderhoff-Müser, Ursula, Stadelmann, Christine, Nizet, Victor, Weber, Joerg R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Major Articles and Brief Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071107/
https://ncbi.nlm.nih.gov/pubmed/21186256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq047
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