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Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis
Pneumococcus is the most common and aggressive cause of bacterial meningitis and induces a novel apoptosis-inducing factor–dependent (AIF–dependent) form of brain cell apoptosis. Loss of production of two pneumococcal toxins, pneumolysin and H(2)O(2), eliminated mitochondrial damage and apoptosis. P...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150815/ https://ncbi.nlm.nih.gov/pubmed/11781347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI12035 |
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