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Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis

Pneumococcus is the most common and aggressive cause of bacterial meningitis and induces a novel apoptosis-inducing factor–dependent (AIF–dependent) form of brain cell apoptosis. Loss of production of two pneumococcal toxins, pneumolysin and H(2)O(2), eliminated mitochondrial damage and apoptosis. P...

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Udgivet i:J Clin Invest
Principais autores: Braun, Johann S., Sublett, Jack E., Freyer, Dorette, Mitchell, Tim J., Cleveland, John L., Tuomanen, Elaine I., Weber, Joerg R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150815/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11781347/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12035
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