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Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis

Meningitis occurs when blood-borne pathogens cross the blood-brain barrier (BBB) in a complex interplay between endothelial cells and microbial gene products. We sought to understand the initial response of the BBB to the human meningeal pathogen group B Streptococcus (GBS) and the organism’s major...

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Detalhes bibliográficos
Main Authors: Doran, Kelly S., Liu, George Y., Nizet, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC182187/
https://ncbi.nlm.nih.gov/pubmed/12952922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317335
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