Adenosine analogue–oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIα)

INTRODUCTION: Type I cGMP-dependent protein kinase (PKGIα) belongs to the family of cyclic nucleotide-dependent protein kinases and is one of the main effectors of cGMP. PKGIα is involved in regulation of cardiac contractility, vasorelaxation, and blood pressure; hence, the development of potent mod...

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Autori principali: Lavogina, Darja, Nickl, Christian K., Enkvist, Erki, Raidaru, Gerda, Lust, Marje, Vaasa, Angela, Uri, Asko, Dostmann, Wolfgang R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071016/
https://ncbi.nlm.nih.gov/pubmed/20406699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2010.04.007
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