Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity

Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely understood, pharmacological donors show broad therapeutic promise and are in clinical trials. Mass spectrometry and site-directed mutagenesis showed that chemically distinct HNO donors 1-nitrosocyclohexyl a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Donzelli, Sonia, Goetz, Mara, Schmidt, Kjestine, Wolters, Markus, Stathopoulou, Konstantina, Diering, Simon, Prysyazhna, Oleksandra, Polat, Volkan, Scotcher, Jenna, Dees, Christian, Subramanian, Hariharan, Butt, Elke, Kamynina, Alisa, Schobesberger, Sophie, King, S. Bruce, Nikolaev, Viacheslav O., de Wit, Cor, Leichert, Lars I., Feil, Robert, Eaton, Philip, Cuello, Friederike
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577323/
https://ncbi.nlm.nih.gov/pubmed/28855531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09275-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados