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Combinational therapy using hypothermia and the immunophilin ligand FK506 to target altered pial arteriolar reactivity, axonal damage, and blood–brain barrier dysfunction after traumatic brain injury in rat

This study evaluated the utility of combinational therapy, coupling delayed posttraumatic hypothermia with delayed FK506 administration, on altered cerebral vascular reactivity, axonal injury, and blood–brain barrier (BBB) disruption seen following traumatic brain injury (TBI). Animals were injured,...

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Autors principals: Oda, Yasutaka, Gao, Guoyi, Wei, Enoch P, Povlishock, John T
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070975/
https://ncbi.nlm.nih.gov/pubmed/21157473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.208
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