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Synthesis of oligodeoxyribonucleotide N3'-->P5' phosphoramidates.

An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen is substituted by a 3'-nitrogen, is described. Synthesis of the title compounds was accomplished by the following synthetic steps. First, 5'-O-DMT base-protected-3'-amino...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Chen, J K, Schultz, R G, Lloyd, D H, Gryaznov, S M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1995
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307090/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7651827/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.14.2661
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