Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming

NUT midline carcinoma (NMC) is a lethal pediatric tumor defined by the presence of BRD-NUT fusion proteins that arrest differentiation. Here we explore the mechanisms underlying the ability of BRD4-NUT to prevent squamous differentiation. In both gain-of and loss-of-expression assays we find that ex...

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Detalhes bibliográficos
Main Authors: Schwartz, Brian E., Hofer, Matthias D., Lemieux, Madeleine E., Bauer, Daniel E., Cameron, Michael J., West, Nathan H., Agoston, Elin S., Reynoird, Nicolas, Khochbin, Saadi, Ince, Tan A., Christie, Amanda, Janeway, Katherine A., Vargas, Sara O., Perez-Atayde, Antonio R., Aster, Jon C., Sallan, Stephen E., Kung, Andrew L., Bradner, James E., French, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070805/
https://ncbi.nlm.nih.gov/pubmed/21447744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3513
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