Загрузка...

Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming

NUT midline carcinoma (NMC) is a lethal pediatric tumor defined by the presence of BRD-NUT fusion proteins that arrest differentiation. Here we explore the mechanisms underlying the ability of BRD4-NUT to prevent squamous differentiation. In both gain-of and loss-of-expression assays we find that ex...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Schwartz, Brian E., Hofer, Matthias D., Lemieux, Madeleine E., Bauer, Daniel E., Cameron, Michael J., West, Nathan H., Agoston, Elin S., Reynoird, Nicolas, Khochbin, Saadi, Ince, Tan A., Christie, Amanda, Janeway, Katherine A., Vargas, Sara O., Perez-Atayde, Antonio R., Aster, Jon C., Sallan, Stephen E., Kung, Andrew L., Bradner, James E., French, Christopher A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070805/
https://ncbi.nlm.nih.gov/pubmed/21447744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3513
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!