Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

Hyaluronan (HA) production has been functionally implicated in prostate tumorigenesis and metastasis. We previously used prostate tumor cells overexpressing the HA synthesizing enzyme HAS3 or the clinically relevant hyaluronidase Hyal1 to show that excess HA production suppresses tumor growth, while...

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Detalhes bibliográficos
Main Authors: Bharadwaj, Alamelu G., Goodrich, Nathaniel P., McAtee, Caitlin O., Haferbier, Katie, Oakley, Gregory G., Wahl, James K., Simpson, Melanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070779/
https://ncbi.nlm.nih.gov/pubmed/21315068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2011.01.026
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