Spontaneous Metastasis of Prostate Cancer Is Promoted by Excess Hyaluronan Synthesis and Processing

Accumulation of extracellular hyaluronan (HA) and its processing enzyme, the hyaluronidase Hyal1, predicts invasive, metastatic progression of human prostate cancer. To dissect the roles of hyaluronan synthases (HAS) and Hyal1 in tumorigenesis and metastasis, we selected nonmetastatic 22Rv1 prostate...

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Hlavní autoři: Bharadwaj, Alamelu G., Kovar, Joy L., Loughman, Eileen, Elowsky, Christian, Oakley, Gregory G., Simpson, Melanie A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2009
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665762/
https://ncbi.nlm.nih.gov/pubmed/19218337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080501
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