Spontaneous Metastasis of Prostate Cancer Is Promoted by Excess Hyaluronan Synthesis and Processing

Accumulation of extracellular hyaluronan (HA) and its processing enzyme, the hyaluronidase Hyal1, predicts invasive, metastatic progression of human prostate cancer. To dissect the roles of hyaluronan synthases (HAS) and Hyal1 in tumorigenesis and metastasis, we selected nonmetastatic 22Rv1 prostate...

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Detalhes bibliográficos
Main Authors: Bharadwaj, Alamelu G., Kovar, Joy L., Loughman, Eileen, Elowsky, Christian, Oakley, Gregory G., Simpson, Melanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665762/
https://ncbi.nlm.nih.gov/pubmed/19218337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080501
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