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Spontaneous Metastasis of Prostate Cancer Is Promoted by Excess Hyaluronan Synthesis and Processing

Accumulation of extracellular hyaluronan (HA) and its processing enzyme, the hyaluronidase Hyal1, predicts invasive, metastatic progression of human prostate cancer. To dissect the roles of hyaluronan synthases (HAS) and Hyal1 in tumorigenesis and metastasis, we selected nonmetastatic 22Rv1 prostate...

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Главные авторы: Bharadwaj, Alamelu G., Kovar, Joy L., Loughman, Eileen, Elowsky, Christian, Oakley, Gregory G., Simpson, Melanie A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665762/
https://ncbi.nlm.nih.gov/pubmed/19218337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080501
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