PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

The current study has addressed the role of PTEN loss in intrinsic resistance to the BRAF inhibitor PLX4720. Immunohistochemical staining of a tissue array covering all stages of melanocytic neoplasia (n=192) revealed PTEN expression to be lost in >10% of all melanoma cases. Although PTEN express...

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Detalhes bibliográficos
Main Authors: Paraiso, Kim H.T., Xiang, Yun, Rebecca, Vito W., Abel, Ethan V., Chen, Y. Ann, Munko, A. Cecilia, Wood, Elizabeth, Fedorenko, Inna V., Sondak, Vernon K., Anderson, Alexander R.A., Ribas, Antoni, Palma, Maurizia Dalla, Nathanson, Katherine L., Koomen, John M., Messina, Jane L., Smalley, Keiran S. M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070772/
https://ncbi.nlm.nih.gov/pubmed/21317224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2954
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