Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations

During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP) was investig...

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Главные авторы: Mutsaers, Henricus A. M., van den Heuvel, Lambertus P., Ringens, Lauke H. J., Dankers, Anita C. A., Russel, Frans G. M., Wetzels, Jack F. M., Hoenderop, Joost G., Masereeuw, Rosalinde
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070735/
https://ncbi.nlm.nih.gov/pubmed/21483698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018438
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