RNAi mediated silencing of Nrf2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Nuclear factor erythroid-2 related factor-2 (Nrf2) is a redox-sensitive transcription factor that regulates the expression of electrophile and xenobiotic detoxification enzymes and efflux proteins, which confer cytoprotection against oxidative stress and apoptosis in normal cells. Loss of function m...

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Bibliographic Details
Main Authors: Singh, Anju, Boldin-Adamsky, Swetlana, Thimmulappa, Rajesh K, Rath, Srikanta K, Ashush, Hagit, Coulter, Jonathan, Blackford, Amanda, Goodman, Steven N, Bunz, Fred, Watson, Walter H, Gabrielson, Edward, Feinstein, Elena, Biswal, Shyam
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070411/
https://ncbi.nlm.nih.gov/pubmed/18829555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1401
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