Pleiotropic Beneficial Effects of Sonic Hedgehog Gene Therapy in an Experimental Model of Peripheral Limb Ischemia

We have previously shown that the signaling pathway of the embryonic morphogen Sonic hedgehog (Shh) is recapitulated in the postnatal skeletal muscle in response to ischemia. We have also demonstrated that Shh is an indirect angiogenic agent upregulating various families of angiogenic growth factors...

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Detalhes bibliográficos
Main Authors: Palladino, Mariangela, Gatto, Ilaria, Neri, Valentina, Straino, Stefania, Silver, Marcy, Tritarelli, Alessandra, Piccioni, Andrea, Smith, Roy C, Gaetani, Eleonora, Losordo, Douglas W, Crea, Filippo, Capogrossi, Maurizio, Pola, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070094/
https://ncbi.nlm.nih.gov/pubmed/21224834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.292
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