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The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis.
The ability of the hammerhead ribozyme to distinguish between matched and mismatched substrates was evaluated using two kinetically defined ribozymes that differed in the length and sequence of the substrate recognition helices. A mismatch in the innermost base pair of helix I affected k2, the chemi...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1995
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306995/ https://ncbi.nlm.nih.gov/pubmed/7610038 |
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