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The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: evidence for a magnesium ion-binding site.

We report details of the synthesis and characterization of oligoribonucleotides containing 4-thiouridine or 2-pyrimidinone ribonucleoside (4HC). We have used these probes to examine the roles of the conserved pyrimidines in the central core of the hammerhead ribozyme. The effects on catalysis of sin...

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Библиографические подробности
Главные авторы: Murray, J B, Adams, C J, Arnold, J R, Stockley, P G
Формат: Artigo
Язык:Inglês
Опубликовано: 1995
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136025/
https://ncbi.nlm.nih.gov/pubmed/7487885
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