Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy

The activin receptor type IIB (ActRIIB) is a transmembrane receptor for transforming growth factor-β superfamily members, including myostatin, that are involved in the negative regulation of skeletal muscle mass. We tested the translational hypothesis that blocking ligand binding to ActRIIB for 12 w...

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Bibliografiska uppgifter
Huvudupphovsmän: Pistilli, Emidio E., Bogdanovich, Sasha, Goncalves, Marcus D., Ahima, Rexford S., Lachey, Jennifer, Seehra, Jasbir, Khurana, Tejvir
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2011
Ämnen:
Regular Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069867/
https://ncbi.nlm.nih.gov/pubmed/21356379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.11.071
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