IGF-1 Has Plaque-Stabilizing Effects in Atherosclerosis by Altering Vascular Smooth Muscle Cell Phenotype

Insulin-like growth factor-1 (IGF-1) signaling is important for the maintenance of plaque stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) phenotype. To investigate this hypothesis, we studied the effects of the highly inflammatory milieu of the atherosclerotic p...

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Bibliographic Details
Main Authors: von der Thüsen, Jan H., Borensztajn, Keren S., Moimas, Silvia, van Heiningen, Sandra, Teeling, Peter, van Berkel, Theo J.C., Biessen, Erik A.L.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2011
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069834/
https://ncbi.nlm.nih.gov/pubmed/21281823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.10.007
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