IGF-1 Has Plaque-Stabilizing Effects in Atherosclerosis by Altering Vascular Smooth Muscle Cell Phenotype

Insulin-like growth factor-1 (IGF-1) signaling is important for the maintenance of plaque stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) phenotype. To investigate this hypothesis, we studied the effects of the highly inflammatory milieu of the atherosclerotic p...

Ausführliche Beschreibung

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Hauptverfasser: von der Thüsen, Jan H., Borensztajn, Keren S., Moimas, Silvia, van Heiningen, Sandra, Teeling, Peter, van Berkel, Theo J.C., Biessen, Erik A.L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2011
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069834/
https://ncbi.nlm.nih.gov/pubmed/21281823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.10.007
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