Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). It is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic leukemia–retinoic acid receptor α (PML-RARA) fusion oncogene. Although this fusion oncogene is known to initiate AP...

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Main Authors: Wartman, Lukas D., Larson, David E., Xiang, Zhifu, Ding, Li, Chen, Ken, Lin, Ling, Cahan, Patrick, Klco, Jeffery M., Welch, John S., Li, Cheng, Payton, Jacqueline E., Uy, Geoffrey L., Varghese, Nobish, Ries, Rhonda E., Hoock, Mieke, Koboldt, Daniel C., McLellan, Michael D., Schmidt, Heather, Fulton, Robert S., Abbott, Rachel M., Cook, Lisa, McGrath, Sean D., Fan, Xian, Dukes, Adam F., Vickery, Tammi, Kalicki, Joelle, Lamprecht, Tamara L., Graubert, Timothy A., Tomasson, Michael H., Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Technical Advance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069786/
https://ncbi.nlm.nih.gov/pubmed/21436584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45284
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