Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). It is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic leukemia–retinoic acid receptor α (PML-RARA) fusion oncogene. Although this fusion oncogene is known to initiate AP...

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Autores principales: Wartman, Lukas D., Larson, David E., Xiang, Zhifu, Ding, Li, Chen, Ken, Lin, Ling, Cahan, Patrick, Klco, Jeffery M., Welch, John S., Li, Cheng, Payton, Jacqueline E., Uy, Geoffrey L., Varghese, Nobish, Ries, Rhonda E., Hoock, Mieke, Koboldt, Daniel C., McLellan, Michael D., Schmidt, Heather, Fulton, Robert S., Abbott, Rachel M., Cook, Lisa, McGrath, Sean D., Fan, Xian, Dukes, Adam F., Vickery, Tammi, Kalicki, Joelle, Lamprecht, Tamara L., Graubert, Timothy A., Tomasson, Michael H., Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2011
Materias:
Technical Advance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069786/
https://ncbi.nlm.nih.gov/pubmed/21436584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45284
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