Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). It is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic leukemia–retinoic acid receptor α (PML-RARA) fusion oncogene. Although this fusion oncogene is known to initiate AP...

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Autori principali: Wartman, Lukas D., Larson, David E., Xiang, Zhifu, Ding, Li, Chen, Ken, Lin, Ling, Cahan, Patrick, Klco, Jeffery M., Welch, John S., Li, Cheng, Payton, Jacqueline E., Uy, Geoffrey L., Varghese, Nobish, Ries, Rhonda E., Hoock, Mieke, Koboldt, Daniel C., McLellan, Michael D., Schmidt, Heather, Fulton, Robert S., Abbott, Rachel M., Cook, Lisa, McGrath, Sean D., Fan, Xian, Dukes, Adam F., Vickery, Tammi, Kalicki, Joelle, Lamprecht, Tamara L., Graubert, Timothy A., Tomasson, Michael H., Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2011
Soggetti:
Technical Advance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069786/
https://ncbi.nlm.nih.gov/pubmed/21436584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45284
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