An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

Pilocytic astrocytoma (PA) is the most common type of primary brain tumor in children and the second most frequent cancer in childhood. Children with incompletely resected PA represent a clinically challenging patient cohort for whom conventional adjuvant therapies are only moderately effective. Thi...

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Bibliografiska uppgifter
Huvudupphovsmän: Gronych, Jan, Korshunov, Andrey, Bageritz, Josephine, Milde, Till, Jugold, Manfred, Hambardzumyan, Dolores, Remke, Marc, Hartmann, Christian, Witt, Hendrik, Jones, David T.W., Witt, Olaf, Heiland, Sabine, Bendszus, Martin, Holland, Eric C., Pfister, Stefan, Lichter, Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2011
Ämnen:
Brief Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069779/
https://ncbi.nlm.nih.gov/pubmed/21403401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44656
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