An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

Pilocytic astrocytoma (PA) is the most common type of primary brain tumor in children and the second most frequent cancer in childhood. Children with incompletely resected PA represent a clinically challenging patient cohort for whom conventional adjuvant therapies are only moderately effective. Thi...

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Detalhes bibliográficos
Main Authors: Gronych, Jan, Korshunov, Andrey, Bageritz, Josephine, Milde, Till, Jugold, Manfred, Hambardzumyan, Dolores, Remke, Marc, Hartmann, Christian, Witt, Hendrik, Jones, David T.W., Witt, Olaf, Heiland, Sabine, Bendszus, Martin, Holland, Eric C., Pfister, Stefan, Lichter, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069779/
https://ncbi.nlm.nih.gov/pubmed/21403401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44656
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