Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans

Autoimmunity has long been linked to myocarditis and its sequela, dilated cardiomyopathy, the leading causes of heart failure in young patients. However, the underlying mechanisms are poorly defined, with most clinical investigations focused on humoral autoimmunity as the target for intervention. He...

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Detalhes bibliográficos
Main Authors: Lv, HuiJuan, Havari, Evis, Pinto, Sheena, Gottumukkala, Raju V.S.R.K., Cornivelli, Lizbeth, Raddassi, Khadir, Matsui, Takashi, Rosenzweig, Anthony, Bronson, Roderick T., Smith, Ross, Fletcher, Anne L., Turley, Shannon J., Wucherpfennig, Kai, Kyewski, Bruno, Lipes, Myra A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069776/
https://ncbi.nlm.nih.gov/pubmed/21436590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44583
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