The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice

Telomerase is activated in most human cancers and is critical for cancer cell growth. However, little is known about the significance of telomerase activation in chromosome instability and cancer initiation. The gene encoding the potent endogenous telomerase inhibitor PinX1 (PIN2/TRF1-interacting, t...

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Bibliographic Details
Main Authors: Zhou, Xiao Zhen, Huang, Pengyu, Shi, Rong, Lee, Tae Ho, Lu, Gina, Zhang, Zhihong, Bronson, Roderick, Lu, Kun Ping
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069765/
https://ncbi.nlm.nih.gov/pubmed/21436583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43452
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