Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are bone metastases, known to usurp HSC homing pathways to establish footholds in the bone marrow. However, it is not clear whether tumors target the HSC niche during metastasis...

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Autores principales: Shiozawa, Yusuke, Pedersen, Elisabeth A., Havens, Aaron M., Jung, Younghun, Mishra, Anjali, Joseph, Jeena, Kim, Jin Koo, Patel, Lalit R., Ying, Chi, Ziegler, Anne M., Pienta, Michael J., Song, Junhui, Wang, Jingcheng, Loberg, Robert D., Krebsbach, Paul H., Pienta, Kenneth J., Taichman, Russell S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069764/
https://ncbi.nlm.nih.gov/pubmed/21436587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43414
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