Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are bone metastases, known to usurp HSC homing pathways to establish footholds in the bone marrow. However, it is not clear whether tumors target the HSC niche during metastasis...

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Main Authors: Shiozawa, Yusuke, Pedersen, Elisabeth A., Havens, Aaron M., Jung, Younghun, Mishra, Anjali, Joseph, Jeena, Kim, Jin Koo, Patel, Lalit R., Ying, Chi, Ziegler, Anne M., Pienta, Michael J., Song, Junhui, Wang, Jingcheng, Loberg, Robert D., Krebsbach, Paul H., Pienta, Kenneth J., Taichman, Russell S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069764/
https://ncbi.nlm.nih.gov/pubmed/21436587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43414
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