Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-5]. LIN28B and its homolog LIN28 (hereafter, LIN28A) are functionally redundant RNA-binding proteins that block let-7 microRNA (miRNA) biogenesis [6-9]. lin-28 and let-7 were disco...

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Hauptverfasser: Zhu, Hao, Shah, Samar, Shyh-Chang, Ng, Shinoda, Gen, Einhorn, William S., Viswanathan, Srinivas R., Takeuchi, Ayumu, Grasemann, Corinna, Rinn, John L., Lopez, Mary F., Hirschhorn, Joel N., Palmert, Mark R., Daley, George Q.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069638/
https://ncbi.nlm.nih.gov/pubmed/20512147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.593
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