Cysteine Proteases Bleomycin Hydrolase and Cathepsin Z Mediate N-terminal Proteolysis and Toxicity of Mutant Huntingtin

N-terminal proteolysis of huntingtin is thought to be an important mediator of HD pathogenesis. The formation of short N-terminal fragments of huntingtin (cp-1/cp-2, cp-A/cp-B) has been demonstrated in cells and in vivo. We previously mapped the cp-2 cleavage site by mass spectrometry to position Ar...

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Bibliografiske detaljer
Main Authors: Ratovitski, Tamara, Chighladze, Ekaterine, Waldron, Elaine, Hirschhorn, Ricky R., Ross, Christopher A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069459/
https://ncbi.nlm.nih.gov/pubmed/21310951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.185348
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