SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC

SmgGDS is an atypical guanine nucleotide exchange factor (GEF) that promotes both cell proliferation and migration and is up-regulated in several types of cancer. SmgGDS has been previously shown to activate a wide variety of small GTPases, including the Ras family members Rap1a, Rap1b, and K-Ras, a...

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Bibliographische Detailangaben
Hauptverfasser: Hamel, Brant, Monaghan-Benson, Elizabeth, Rojas, Rafael J., Temple, Brenda R. S., Marston, Daniel J., Burridge, Keith, Sondek, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069418/
https://ncbi.nlm.nih.gov/pubmed/21242305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191122
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