The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues

This review focuses on topical issues in the biology and treatment of the myeloproliferative neoplasms (MPNs). Studies in transgenic mice suggest that BCR-ABL1 reduces the fraction of self-renewing ‘leukemic’ stem cells in the bone marrow but that some of these cells survive treatment with imatinib....

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Detalhes bibliográficos
Main Authors: Van Etten, Richard A., Koschmieder, Steffen, Delhommeau, Francois, Perrotti, Danilo, Holyoake, Tessa, Pardanani, Animesh, Mesa, Ruben, Green, Tony, Ibrahim, Amr R., Mughal, Tariq, Gale, Robert Peter, Goldman, John
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069237/
https://ncbi.nlm.nih.gov/pubmed/21242185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.035675
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