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Evolutionary approach to predicting the binding site residues of a protein from its primary sequence

Protein binding site residues, especially catalytic residues, play a central role in protein function. Because more than 99% of the ∼12 million protein sequences in the nonredundant protein database have no structural information, it is desirable to develop methods to predict the binding site residu...

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Autori principali: Tseng, Yan Yuan, Li, Wen-Hsiung
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069214/
https://ncbi.nlm.nih.gov/pubmed/21402946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102210108
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