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Evolutionary population genetics of promoters: Predicting binding sites and functional phylogenies
We study the evolution of transcription factor-binding sites in prokaryotes, using an empirically grounded model with point mutations and genetic drift. Selection acts on the site sequence via its binding affinity to the corresponding transcription factor. Calibrating the model with populations of f...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276062/ https://ncbi.nlm.nih.gov/pubmed/16236723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505537102 |
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