Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA.
Hot piperidine is often used to cleave abasic and UV-irradiated DNA at the sites of damage. It can inflict non-specific damage on DNA, probably because it is a strong base and creates significant concentrations of hydroxyl ions which can attack purines and pyrimidines. We show that several other ami...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1995
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| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7784169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.10.1664 |
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