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Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA.

Hot piperidine is often used to cleave abasic and UV-irradiated DNA at the sites of damage. It can inflict non-specific damage on DNA, probably because it is a strong base and creates significant concentrations of hydroxyl ions which can attack purines and pyrimidines. We show that several other ami...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Principais autores: McHugh, P J, Knowland, J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1995
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306919/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7784169/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.10.1664
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