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Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA.
Hot piperidine is often used to cleave abasic and UV-irradiated DNA at the sites of damage. It can inflict non-specific damage on DNA, probably because it is a strong base and creates significant concentrations of hydroxyl ions which can attack purines and pyrimidines. We show that several other ami...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
1995
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306919/ https://ncbi.nlm.nih.gov/pubmed/7784169 |
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