Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-β-TrCP, sequentially regulate glycolysis during the cell cycle

During cell proliferation, the abundance of the glycolysis-promoting enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, isoform 3 (PFKFB3), is controlled by the ubiquitin ligase APC/C-Cdh1 via a KEN box. We now demonstrate in synchronized HeLa cells that PFKFB3, which appears in mid-to-la...

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Bibliografiske detaljer
Main Authors: Tudzarova, Slavica, Colombo, Sergio L., Stoeber, Kai, Carcamo, Saul, Williams, Gareth H., Moncada, Salvador
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069186/
https://ncbi.nlm.nih.gov/pubmed/21402913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102247108
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