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Redesigning allosteric activation in an enzyme

Enzyme activation by monovalent cations is widely documented in plants and the animal world. In type II enzymes, activation entails two steps: binding of the monovalent cation to its allosteric site and transduction of this event into enhanced catalytic activity. The effect has exquisite specificity...

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Bibliographic Details
Main Authors: Rana, Sadhna, Pozzi, Nicola, Pelc, Leslie A., Di Cera, Enrico
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069170/
https://ncbi.nlm.nih.gov/pubmed/21368156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018860108
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