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Determinism and stochasticity during maturation of the zebrafish antibody repertoire

It is thought that the adaptive immune system of immature organisms follows a more deterministic program of antibody creation than is found in adults. We used high-throughput sequencing to characterize the diversifying antibody repertoire in zebrafish over five developmental time points. We found th...

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Bibliografische gegevens
Hoofdauteurs: Jiang, Ning, Weinstein, Joshua A., Penland, Lolita, White, Richard A., Fisher, Daniel S., Quake, Stephen R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069157/
https://ncbi.nlm.nih.gov/pubmed/21393572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014277108
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