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Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

BACKGROUND: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention. METHODOLOGY/PRINCIPAL FINDINGS: We present a method for structure-ba...

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書誌詳細
主要な著者: Löwer, Martin, Geppert, Tim, Schneider, Petra, Hoy, Benjamin, Wessler, Silja, Schneider, Gisbert
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069028/
https://ncbi.nlm.nih.gov/pubmed/21483848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017986
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